What would it mean for your HFrEF patients to feel better?
PARADIGM-HF evaluated patients' overall quality of life (QoL) using the KCCQ-23, which includes these domains1,2:
Each domain is scored on a scale of 0-100; higher scores indicate better health status.
The KCCQ-23 Clinical Summary score (CS) represents the average of the symptom (frequency and burden) and physical limitation domains.1,2
Analysis included all patients with at least 1 KCCQ data up to month 8. For patients who died, the worst score (0) was imputed for the CS at all subsequent scheduled visits.
Change in the KCCQ-23 CS from baseline to 8 months was a prespecified secondary outcome in PARADIGM-HF.1,3
Mean change in KCCQ-23 CS at 8-month, double-blind period: ENTRESTO -2.99 (n=4187), enalapril -4.63 (n=4212). Clinically meaningful difference established as 5 points.3