Dosing & Titration | ENTRESTO® (sacubitril/valsartan) | HCP

Start ENTRESTO^® with confidence

ENTRESTO is available in 3 dosage strengths¹

Pills shown not actual size.

How to prescribe ENTRESTO to your adult patients

Choose initial dose of ENTRESTO based on current treatment and titrate to the target dose¹

SWITCHING FROM A LOWER DOSE OR NOT CURRENTLY ON AN ACEi OR ARB¹:

SWITCHING FROM A HIGHER DOSE OF AN ACEi OR ARB¹:

ENTRESTO is contraindicated with concomitant use of an ACEi and in patients with a history of angioedema related to previous ACEi or ARB therapy¹
Avoid use of ENTRESTO with an ARB, because ENTRESTO contains the angiotensin II receptor blocker valsartan¹

Unless your patient is on a high ACEi/ARB dose, start ENTRESTO at 24/26 mg twice daily and double the dose every 2 to 4 weeks, as tolerated by the patient. When switching from an ACEi, be sure to allow for a 36-hour washout period prior to initiating ENTRESTO.¹

DOSING IN PATIENTS WITH RENAL OR HEPATIC IMPAIRMENT

*In PARAGON-HF, defined as LVEF ≥45% with structural heart disease (LAE or LVH); median LVEF was 57%. LVEF is a variable measure and the normal range can vary.¹

Definitions & References

Definitions
ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin ‖ receptor blocker; LAE, left atrial enlargement; LVH, left ventricular hypertrophy.

References
1. ENTRESTO [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corp.
2. Senni M, McMurray JJV, Wachter R, et al. Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double-blind, randomized comparison of two uptitration regimens. Eur J Heart Fail. 2016;18(9):1193-1202. doi:10.1002/ejhf.548