Dosing & Titration | ENTRESTO® (sacubitril/valsartan)

Start ENTRESTO^® with confidence

ENTRESTO is available in 3 dosage strengths¹

Pills shown not actual size.

How to prescribe ENTRESTO to your adult patients

Choose initial dose of ENTRESTO based on current treatment and titrate to the target dose¹

SWITCHING FROM A LOWER DOSE OR NOT CURRENTLY ON AN ACEi OR ARB¹:

SWITCHING FROM A HIGHER DOSE OF AN ACEi OR ARB¹:

ENTRESTO is contraindicated with concomitant use of an ACEi and in patients with a history of angioedema related to previous ACEi or ARB therapy¹
Avoid use of ENTRESTO with an ARB, because ENTRESTO contains the angiotensin II receptor blocker valsartan¹

Unless your patient is on a high ACEi/ARB dose, start ENTRESTO at 24/26 mg twice daily and double the dose every 2 to 4 weeks, as tolerated by the patient. When switching from an ACEi, be sure to allow for a 36-hour washout period prior to initiating ENTRESTO.¹

DOSING IN PATIENTS WITH RENAL OR HEPATIC IMPAIRMENT

*In PARAGON-HF, defined as LVEF ≥45% with structural heart disease (LAE or LVH); median LVEF was 57%. LVEF is a variable measure and the normal range can vary.¹

Indication

ENTRESTO is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure. Benefits are most clearly evident in patients with left ventricular ejection fraction (LVEF) below normal.

LVEF is a variable measure, so use clinical judgment in deciding whom to treat.

Start ENTRESTO^® with confidence

ENTRESTO is available in 3 dosage strengths¹

How to prescribe ENTRESTO to your adult patients

SWITCHING FROM A LOWER DOSE OR NOT CURRENTLY ON AN ACEi OR ARB¹:

SWITCHING FROM A HIGHER DOSE OF AN ACEi OR ARB¹:

DOSING IN PATIENTS WITH RENAL OR HEPATIC IMPAIRMENT

How to prescribe ENTRESTO for severe renal impairment (eGFR <30mL/min/1.73 m²) or moderate hepatic impairment (Child-Pugh B classification)¹

Important Safety Information

Indication

Definitions & References

Start ENTRESTO® with confidence

ENTRESTO is available in 3 dosage strengths1

How to prescribe ENTRESTO to your adult patients

SWITCHING FROM A LOWER DOSE OR NOT CURRENTLY ON AN ACEi OR ARB1:

SWITCHING FROM A HIGHER DOSE OF AN ACEi OR ARB1:

DOSING IN PATIENTS WITH RENAL OR HEPATIC IMPAIRMENT

Important Safety Information

Indication

Definitions & References

Start ENTRESTO^® with confidence

ENTRESTO is available in 3 dosage strengths¹

SWITCHING FROM A LOWER DOSE OR NOT CURRENTLY ON AN ACEi OR ARB¹:

SWITCHING FROM A HIGHER DOSE OF AN ACEi OR ARB¹: